As long as there are additional cable ports for the SATA and power, an adapter for the 5.25" bay is common. One like this: https://www.amazon.com/Kingwin-Internal-3-5-Inch-5-25-Inch-HDM-229/dp/B00A659K2I/ref=pd_lpo_147_lp_t_4?_encoding=UTF8&psc=1&refRID=CQ04ZTMS7EWXD6FPN41X
That is the simplest adapter, as long as the drive bay is empty.