Mtothaj,
I've never used them, but ASUS has a quite good range of PCIe sound cards, from 2-channel to 7.1. The specifications and reviews / reputation are generally positive.
For years, I've been very happy with PCI sound cards as a way to use that slot. I've used M-Audio 192 "Audiophiles" since 2009 and I have one now in the main z420 (E5-1660 v2 / 32GB / Quadro K4200 / Win7) , in an HP m9426f which is a deidecated sound system (live and MIDI) another in the Dell E520 that runs the television, another in a Dell Precision T5500, and the junior one , the "2496" in the secondary z420 and in a Precision T3500.
The advantage of those is that they are duplex recording cards with MIDI I/O and SPDIF. Using Cakewalk and Steinberg software, these have made many quite good live and MIDI recordings, including a few that were broadcast. I've not used Windows 10, but the Windows 7 and 8 drivers are said to work in Win 10. The 192 uses 1/4" instruments jacks and the 2496 has RCA. I bought most of these cards used and never had a failure or problems after hundreds of recordings and thousands of hours of playback.
The office z620 (2X E5-2690 / 64GB / Quadro K2200 + Tesla M090/ Win7) however has a conflict as the double height Tesla M2090 covers the PCI slot. This system is probably going to have a USB interface with at least 2-in / 4 out plus MIDI. Without the M2090 it would have an M-Audio 192.
The dedicated sound system playback uses Audio Research LS3 /D130 with Infinity 360 speakers but in the office, I've had good general results with Logitech 2.1 systems, the obsolete z2300 in particular. Some models have a wired remote with on/off, volume, and a headphone jack and that's very convenient. I'm giving a couple of Logitech z323 systems as gifts this year which are lower cost and still have the wired remote.
I'd never heard HP z integrated sound until about three weeks ago with the z620 and while it's quite acceptable, the dedicated sound card is simply better and much more enjoyable over a long listening period.
Cheers,
BambiBoomZ