Hi Chris,
I have also added M.2 PCIe drive to my Z620. The details are showm here;
I initially installed the Samsung SM951 using the standard install method (AHCI install) and simply cloned my OS drive to the new SM951 using MiniTool Partition Wizard. I eventually decided to go for the UEFI boot and I have also included this in the post (on the 3rd page). It did make a significant difference in my disk Passmark score increasing from circa 8000 to circa 13000 so in my opinion, worth the hassle.
Something which you will need;
http://h20564.www2.hp.com/hpsc/doc/public/display?docId=c03465686
You could also go down the Z Turbo route and I'm sure there are a few examples listed on the forum.